Product Pipeline

  Phase 1 Phase 2 Phase 3 Filing Approved

ALPROLIX is a recombinant factor IX Fc fusion protein for the treatment of hemophilia B. Biogen Idec and Swedish Orphan Biovitrum (Sobi) are partners in the development and commercialization of ALPROLIX.

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AVONEX (INTERFERON BETA-1A)
Multiple Sclerosis, Relapsing forms

AVONEX (Interferon beta-1a) is a leading therapeutic for relapsing forms of MS to slow the progression of disability and reduce relapses. AVONEX is also approved for patients who have their first clinical MS attack and have a brain MRI scan consistent with MS.

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ELOCTATE is a recombinant B-domain deleted factor VIII Fc fusion protein for the treatment of hemophilia A. Biogen Idec and Swedish Orphan Biovitrum (Sobi) are collaborators in the development and commercialization of ELOCTATE.

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FAMPYRA (PROLONGED-RELEASE FAMPRIDINE TABLETS)
Multiple Sclerosis (Walking Ability)

FAMPYRA is an investigational oral, prolonged-release formulation of 4-aminopyridine, that has been developed to improve walking ability in adult patients with multiple sclerosis (MS). Studies have shown that fampridine can increase conduction velocity along damaged nerves, which may result in improved neurological function. This compound is approved in the US (where it is known as AMPYRA) and is being commercialized outside of the US by Biogen Idec under a licensing agreement with Acorda Therapeutics.

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FUMADERM (FUMARIC ACID ESTERS)
Psoriasis (Germany)

FUMADERM is an oral product containing fumaric acid esters, and was approved in Germany in 1994 for treatment of severe psoriasis. Acquired with the Fumapharm purchase.

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GAZYVA (HUMANIZED ANTI-CD20 MAB)
Chronic Lymphocytic Leukemia

Humanized monoclonal antibody specific for CD20. Humanized anti-CD20 mAb is being developed under a collaboration agreement with Genentech, a wholly-owned member of the Roche Group.

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PLEGRIDY (PEGINTERFERON beta-1a)
Multiple Sclerosis, Relapsing Forms

PLEGRIDY™ (peginterferon beta-1a) is a subcutaneous injectable therapy for relapsing forms of multiple sclerosis (RMS), in which interferon beta-1a is pegylated to extend its half-life to permit a less frequent dosing schedule. PLEGRIDY is a member of the interferon class of treatments for MS.

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RITUXAN (RITUXIMAB)
Non-Hodgkin's Lymphoma

We collaborate with Genentech on the development and commercialization of RITUXAN.

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RITUXAN (RITUXIMAB)
ANCA-Associated Vasculitis

We collaborate with Genentech on the development and commercialization of RITUXAN.

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RITUXAN (RITUXIMAB)
Anti-TNF Refractory Rheumatoid Arthritis

We collaborate with Genentech on the development and commercialization of RITUXAN.

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RITUXAN (RITUXIMAB)
Chronic Lymphocytic Leukemia

We collaborate with Genentech on the development and commercialization of RITUXAN.

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TECFIDERA (DIMETHYL FUMARATE)
Multiple Sclerosis, Relapsing Forms

Small molecule immune modulator, oral formation. Acquired with Fumapharm purchase.

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TYSABRI (NATALIZUMAB)
Multiple Sclerosis, Relapsing-Remitting

TYSABRI (Natalizumab) has advanced the treatment of MS patients with established efficacy. It has been proven to reduce flare-ups and slow physical disability progression.

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TYSABRI (NATALIZUMAB)
Crohn's Disease (U.S.)
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DACLIZUMAB HYP
Multiple Sclerosis, Relapsing Forms

Humanized antibody specific for IL2 receptor. Daclizumab HYP is an investigational therapy under a collaboration agreement with Abbvie Biotherapeutics.

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ISIS-SMNrx
Spinal Muscular Atrophy

Antisense investigational therapy for the treatment of Spinal Muscular Atrophy (SMA), in collaboration with Isis Pharmaceuticals.

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OBINUTUZUMAB (GA101)
Diffuse large B-cell lymphoma

Glycoengineered, type II, humanized anti-CD20 monoclonal antibody. We collaborate on obinutuzumab in the U.S. with Genentech, Inc., a wholly-owned member of the Roche Group. The Roche Group and its sub-licensees maintain sole responsibility for the development, manufacturing and commercialization of obinutuzumab.

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OBINUTUZUMAB (GA101)
Non-Hodgkin’s Lymphoma, Front-line Indolent

Glycoengineered, type II, humanized anti-CD20 monoclonal antibody. We collaborate on obinutuzumab in the U.S. with Genentech, Inc., a wholly-owned member of the Roche Group. The Roche Group and its sub-licensees maintain sole responsibility for the development, manufacturing and commercialization of obinutuzumab.

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OBINUTUZUMAB (GA101)
Non-Hodgkin’s Lymphoma, Refractory Indolent

Glycoengineered, type II, humanized anti-CD20 monoclonal antibody. We collaborate on obinutuzumab in the U.S. with Genentech, Inc., a wholly-owned member of the Roche Group. The Roche Group and its sub-licensees maintain sole responsibility for the development, manufacturing and commercialization of obinutuzumab.

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NATALIZUMAB
Multiple Sclerosis, Secondary-Progressive

Natalizumab is being investigated for the treatment of secondary-progress multiple sclerosis.

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Anti-LINGO
Multiple Sclerosis

Investigational therapy for the treatment of multiple sclerosis.

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ANTI-TWEAK
Lupus Nephritis

Humanized monoclonal antibody specific for TWEAK.

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BAN2401
Alzheimer's Disease

Humanized monoclonal antibody being investigated for the treatment of Alzheimer’s disease in collaboration with Eisai, Co. Ltd.

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Natalizumab
Acute Ischemic Stroke

Natalizumab is being investigated for the treatment of acute ischemic stroke.

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Neublastin
Neuropathic Pain

Investigational therapy for the treatment of neuropathic pain.

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STX-100
Idiopathic Pulmonary Fibrosis

Novel humanized monoclonal antibody being investigated for the treatment of idiopathic pulmonary fibrosis (IPF).

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Anti-CD40 Ligand (CDP7657)
Systemic Lupus Erythematosus

Investigational therapy for the treatment of systemic lupus erythematosus.

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Investigational therapy for the treatment of Alzheimer's disease.

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BIIB059 (Anti-BDCA2)
Systemic Lupus Erythematosus

Investigational therapy for systemic lupus erythematosus.

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BIIB061
Multiple Sclerosis, Oral Remyelination

Investigational therapy for the treatment of multiple sclerosis through remyelination.

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E2609
Alzheimer's Disease

E2609 is a BACE inhibitor being investigated for the treatment of Alzheimer’s disease in collaboration with Eisai, Co. Ltd.

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ISIS-DMPKRX
Myotonic Dystrophy, Type 1

Investigational therapy for the treatment of Type 1 myotonic dystrophy in development in collaboration with Isis Pharmaceuticals.

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